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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis's side effects.azole antifungal medications 'on-demand' until sex? We don't know yet.
  • Read more about these before taking Cialis.
  • Facial flushing
  • Swelling of the eyes
  • Muscle aches
  • Back pain
  • Flu-like symptoms
  • If you experience any of the above side effects, seek medical attention immediately.

    Tell them about any and all medications, prescription drugs, and supplements you are taking before starting Cialis.

    As with all prescription medications, inform your doctor of any medical condition you

    View more about Cialis's side effects.Read more about how long it takes for Cialis to work.
  • Read more about these when using Cialis.
  • Swelling in the eyes
  • Show side effects of Cialis - how long does it take for Cialis to work.

    What is Cialis?

    Cialis is a prescription medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).

    This medication works by increasing blood flow to the penis during sexual stimulation. Cialis belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.

    As a result of increased blood flow, the pressure in the lungs decreases, making it easier to get or keep an erection.

    Cialis does not protect against HIV, pregnancy, sexually transmitted diseases, or sexually transmitted infections (such as ).

    Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

    Common side effects reported from Cialis use include:

    • Headache
    • Indigestion
    • Heartburn
    • Upset stomach
    • Gas
    • Nausea
    • Flushing

    More severe side effects include:

    • Painful erections or erections that last longer than 4 hours
    • Sudden loss of vision
    • Sudden loss of hearing
    • Ringing in the ears
    • Chest pain
    • Shortness of breath
    • Painful urination
    • Increased urination frequency
    • Fainting
    • Dizziness
    • Skin rash
    • Hives
    • Facial swelling

    If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

    As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

    Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

    In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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    Cialis can cause potentially serious adverse reactions in some people. Specifically, it can cause dizziness, fainting, and pain in the arms and legs. If you experience any unusual thoughts or symptoms, contact your health care provider.

    furosemide Gastrointestinal distress Symptoms of gastrointestinal distress Go to the Emergency Department of your health care provider with any concerns or questions.

    If you experience any difficulty while taking Cialis, inform your health care provider. This may be a sign of serious side effects. Specifically, you should tell your health care provider that you are taking Cialis or any other nitrates while taking Cialis. This may lead to serious health conditions or death.

    Tell them if you have any medical, psychological, or lifestyle factors that may contribute to your experiences with Cialis. This includes family history of erectile dysfunction, thyroid problems, panic disorder, depression, heart disease, low blood pressure, low testosterone, lupus, anxiety, or food intolerances.

    In addition, let your doctor know if you are pregnant or plan on becoming pregnant. If you become pregnant, contact your health care provider immediately.

    Makenatal Tablets Cialis can cause potentially serious reactions in some people. Specifically, it can cause potentially serious reactions in some people.

    In addition, let your health care provider know if you are breastfeeding. Cialis can cause potentially serious reactions in some people. This may lead you to suffering from a serious medical condition or death.

    In addition, let your doctor know if you currently have diabetes, have high blood pressure, have a heart problem, or if you are taking any other medications.

    In addition, let your doctor know if you are pregnant or plan to become pregnant.

    1. Introduction

    In the early 1980s, pharmaceutical companies began to produce and market a variety of medicines, including Viagra®, Cialis®, Levitra®, and the generic versions of the drug Viagra® and Cialis® (Table [1]). In the United States, the number of medicines sold is steadily increasing, and the prevalence of erectile dysfunction is growing rapidly. In many parts of the world, erectile dysfunction affects men and causes a large number of men to seek treatment for the condition. There are several effective drugs for treating erectile dysfunction, such as Viagra® and Cialis® (Table [1]).

    The treatment of erectile dysfunction is most effective when it is combined with a medication (or combination of the two) that increases blood flow to the penis. This leads to an erection. The main objective of this drug combination is to treat the condition by increasing blood flow to the penis and improving the sexual performance of the male partner.

    In the case of erectile dysfunction, a person’s blood flow to the penis is decreased, and erectile dysfunction may also be treated with medications that improve blood flow to the penis, such as phosphodiesterase type 5 (PDE5) inhibitors, tadalafil, and sildenafil (Table [1]).

    2. Uses of the Drug

    The drug of choice for erectile dysfunction is PDE5 inhibitors. These medicines are used to treat erectile dysfunction. PDE5 inhibitors are mainly used for the treatment of erectile dysfunction in men. PDE5 inhibitors work by blocking the enzyme responsible for the breakdown of cyclic GMP, a substance that regulates blood flow in the penis. These medicines increase blood flow to the penis and improve its hardness and firmness.

    3. Mechanism of Action

    The mechanism of action of PDE5 inhibitors is to improve blood flow to the penis, which helps to improve the sexual performance of the male partner.

    This drug is also used to treat pulmonary hypertension, which affects people with high blood pressure, and it is also used in erectile dysfunction to treat pulmonary hypertension. The drug is effective in treating erectile dysfunction in men. The drug also lowers the risk of developing cardiovascular events in patients who are at high risk of cardiovascular disease, such as heart failure, stroke, and other heart-related disorders.

    PDE5 inhibitors can also be used as an adjunct to other treatment modalities, such as surgery, chemotherapy, radiation, and other medications for treating certain diseases.

    It is also used to treat benign prostatic hyperplasia, a condition in which the prostate gland enlarges causing symptoms such as pain, difficulty in urinating, and frequent urination, and it can also be used in combination with medications used for prostate surgery to improve the blood flow to the prostate. The drug also acts as an inhibitor of prostaglandin synthesis, which is important for the vasodilation of the prostate.

    4. Side Effects

    Side effects of the drug are similar to those of other medicines. The most common ones include the following:

    • Headache
    • Diarrhea
    • Dizziness
    • Nausea
    • Rash
    • Facial flushing
    • Nasal congestion
    • Nasal congestion and pain
    • Dyspepsia

    In addition, the following have been reported by patients with erectile dysfunction:

    • Flushing
    • Dryness of the skin
    • Pelvic pain
    • Abnormal vaginal bleeding

    5. Warnings

    There are some precautions and warnings for patients who take PDE5 inhibitors.

    • Patients should be advised not to take the drug if they are pregnant, breastfeeding, or have kidney problems. This drug can increase the risk of birth defects in babies, especially in the first few months of life.

    Interactions

    A. Top Drug-Drug Interactions:

    1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

    2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

    3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

    Other Drug-Drug interactions:

    • Ketoconazole, itraconazole (used to manage fungal infection)
    • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
    • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
    • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
    • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

    B. Drug-Food Interactions:

    Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

    1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
    2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
    3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
    4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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    Grapefruit and Grapefruit Juice:

    While grapefruit and grapefruit juice are safe and effective when taken as prescribed, they may cause side effects, including that from alcohol. The following escalated to the misuse of these beverages:

    1. : TheseProducts contain grapefruit.
    2. Driedurga,riederup: These contain driedurga.
    3. Driedurga,rindopinirole,rythromycin: These are based on dryriben.
    4. Black coffee grounds: These contains black coffee grounds.
    5. : These grounds.